Treatment Halves Preterm Birth Rate

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The risk of preterm birth and neonatal mortality and morbidity declined significantly in asymptomatic women with a ... short cervix treated with vaginal progesterone ...

The treatment was associated with a 40% to 50% reduction in the risk of preterm birth, a 43% reduction in total neonatal morbidity and mortality, and a 45% reduction in the frequency of low birth weight.

... "Our analysis provides compelling evidence that vaginal progesterone prevents preterm birth and reduces neonatal morbidity and mortality in women with a short cervix," ...

"Importantly, progesterone reduced early preterm birth. These immature babies are at the greatest risk for complications, death, and long-term disability. Progesterone also decreased a fraction of late preterm births, which are the most common preterm deliveries."

... Progesterone has a key role in maintenance of pregnancy ...

"Vaginal progesterone was associated with a significant reduction in the risk of preterm birth <33 weeks of gestation in both women with a single gestation and no previous preterm birth, as well as in women with a single gestation and at least one previous spontaneous preterm birth before 37 weeks of gestation," ...

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